Dermal fillers come in a variety of formulations, each with its own “profile,” though the core purpose is to increase volume in a specific area or in a fold, crease, or wrinkle. Evolysse is the latest hyaluronic gel filler, offering similar uses and longevity. The one difference is in the manufacturing. While other dermal fillers rely on a process involving heat, Evolysse is prepared at near-freezing temperatures.
This cold process is designed to lessen the fragmentation and cross-linking within the gel. Cross-linking is what makes fillers softer or firmer and inevitably affects their longevity and pliability once injected into the skin. To learn more about Evolysse in Los Angeles, contact us today.
At Rebecca Fitzgerald, MD, Dr. Fitzgerald has built a reputation for staying at the forefront of injectable innovation in Los Angeles. Adding Evolysse filler to her practice reflects that same commitment—offering patients access to one of the most recently developed hyaluronic acid options available, backed by rigorous European clinical research and a manufacturing process genuinely distinct from anything that came before it.
Evolysse was developed and is manufactured by SYMATESE, a French research and development company focused on the science of tissue regeneration and reconstruction for over 25 years. Evolus in California is the distribution partner in the United States.
Dr. Fitzgerald has included Evolysse as a new dermal filler option that is positioned alongside long-time filler offerings, such as Restylane, Juvederm, and RHA brands. As with certain other filler formulations, clinical trials show Evolysse with up to 12 months’ duration. Evolysse is also demonstrating natural retention of movement in the injected areas. As always, injector technique and skill make a major difference in how fillers fulfill the needs of each patient. Learn more about patient safety here.
Evolysse is offered in two formulations in the United States. Both formulations contain lidocaine to provide comfort during injection.
Both options are available at our Los Angeles practice, and Dr. Fitzgerald will help you determine which Evolysse formulation is best suited to your facial anatomy and treatment goals.

Brittany received 0.55 mL of Evolysse Form in her smile lines and 0.4 mL of Evolysse Smooth in her marionette lines and chin crease.

Brooke received 0.9 mL of Evolysse Form in her smile lines and 0.4 mL of Evolysse Smooth in her marionette lines and chin crease.
Most adults who are bothered by moderate facial lines, lost volume around the mouth, or deepening nasolabial folds are good candidates for Evolysse treatment. Because both formulations contain lidocaine, the experience is generally well tolerated, which makes it accessible to patients who have been hesitant about discomfort with other fillers.
Ideal candidates are adults in good general health who are not pregnant or nursing and have realistic expectations about what a non-surgical injectable can achieve. Patients who have previously responded well to hyaluronic acid fillers from other brands may find Evolysse a natural next step, particularly if they are interested in a product with a cold-process manufacturing profile. During your consultation at our Los Angeles practice, Dr. Fitzgerald will review your facial anatomy, discuss your goals, and determine whether Evolysse Form, Evolysse Smooth, or another option in our portfolio is the right fit for you.
If you are interested in Evolysse in Los Angeles, reach out to us today. Rebecca Fitzgerald, MD, is a center of excellence in cosmetic dermatology, and our approach to injectable treatment reflects that standard at every level. Dr. Fitzgerald and her colleagues bring decades of combined expertise to every patient who walks through our doors, and every recommendation is grounded in a thorough understanding of facial anatomy, product science, and individual goals.
Whether you are new to fillers or looking to refine a treatment plan that has served you well, we are here to help you move forward with clarity and confidence. To schedule your consultation for Evolysse at Rebecca Fitzgerald MD, contact our office today.
The primary distinction is in how it is manufactured. Most HA fillers are cross-linked using a heat-based process. Evolysse uses a cold-process method, which is designed to preserve the integrity of the hyaluronic acid chains and reduce fragmentation. The result is a gel with a distinct texture profile that may behave differently once injected, particularly in terms of movement and pliability.
Clinical data shows that Evolysse can last up to 12 months, which is consistent with many established HA fillers. Individual results will vary depending on factors like the treatment area, the volume injected, your metabolism, and how your skin responds over time. Dr. Fitzgerald will give you a realistic sense of what to expect based on your specific anatomy during your Los Angeles consultation.
Both Evolysse formulations contain lidocaine, a local anesthetic that helps minimize discomfort during injection. Patients consistently report that the treatment is far more comfortable than they anticipated. For those with heightened sensitivity, additional numbing options can be discussed ahead of your appointment.
Yes. Dr. Fitzgerald regularly works with patients across a full range of injectable and non-injectable treatments, and our cross-referral model means you have access to the expertise of Dr. H. Ray Jalian and Dr. Helen H. Fincher as well. Depending on your goals, Evolysse may be used alongside neurotoxins, other fillers, or laser treatments for a more comprehensive result.